Our lab studies age-related cognitive decline in a nonhuman primate with a short lifespan, the common marmoset. We use an integrative approach to investigate how biological sex and sex steroids affect healthy and pathological neurocognitive aging.

Normal Aging and Alzheimer's disease

​Are there sex differences in the trajectories of age-related cognitive decline ? ​Can we identify predictors of pathological aging? 

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Women's health

Estrogen loss due to menopause or certain cancer treatments is associated with cognitive deficits, sleep and emotional disturbances and hot flashes. Our studies seek to understand mechanisms and finding safe treatments

congratulations !!!

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- Mélise Edwards wins a FORD FELLOWSHIP !

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- Jen Jeong, Taylor Schmeizer and Alexis Veautour complete their Honors Theses and are on their way to vet school !

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- ​​Emily Rothwell awarded a postdoctoral NIH F32 award !

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Check out new papers by lab members !

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Rothwell, E.S., Workman, K. P., Edwards, M., Freire Cobo, C., Varghese, M., Janssen W., Hof, P.R., Lacreuse, A. (2021, in press) The marmoset as an important primate model for longitudinal studies of neurocognitive aging. American Journal of Primatology. Special Issue “Aging, Cognitive Decline, and Neuropathology in Nonhuman Primates”

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Nephew, B. Febo, M., Cali, R., Workman, K. P., Payne, L., Moore, C.M., King, J.A. and Lacreuse, A. (2020). Robustness of sex-differences in functional connectivity over time in middle-aged marmosets. Scientific Reports, 10, 16647.

Lacreuse, A, Raz, N, Schmidtke, D, Hopkins, W.D & Herndon, JG (2020). Age-related decline in executive function as a hallmark of cognitive aging in primates: an overview of cognitive and neurobiological studies. Invited paper, Special issue on “"Evolution of the Primate Aging Process", Philosophical Transactions of the Royal Society B.

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Vaughan E, Le A, Casey M, Workman K & Lacreuse, A (2019). Baseline cortisol levels and social behavior differ as a function of handedness in marmosets (Callithrix jacchus). American Journal of Primatology;81:e23057.

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LaClair M, Febo M, Nephew B, Gervais NJ, Poirier G, Workman K, Chumachenko S, Payne L, Moore MC, King JA & Lacreuse, A. (2019). Sex differences in cognitive flexibility and resting brain networks in middle-aged marmosets. eneuro:ENEURO.0154-19.2019.

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related media https://blogs.umass.edu/ions/2019/07/02/sexdifferencesmarmosets/

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Gervais, N. J., Remage-Healey, L., Starrett, J. R., Pollak, D. J., Mong, J. A., & Lacreuse, A. (2018). Adverse effects of aromatase inhibition on the brain and behavior in a non-human primate. J Neurosci. doi: 10.1523/jneurosci.0353-18.2018

 

Workman, K. P., Healey, B., Carlotto, A., & Lacreuse, A. (2018). One‐year change in cognitive flexibility and fine motor function in middle‐aged male and female marmosets (Callithrix jacchus). American journal of primatology, e22924.